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Enumerating the focus score, the results indicated that male and female diseased B6. NOD-Aec1Aec2 displayed higher numbers of neutrophils and macrophages than their male counterparts whereas minimal numbers of neutrophils and macrophages were detected in both sexes of B6 and B6.
NOD-Aec1Aec2 mice exhibited higher focus scores (1.250 ± 0.313, 1.619 ± 0.381, respectively) in comparison to male and female B6 (0.400 ± 0.163, 0.385 ± 0.140) or B6. Il17 mice showed smaller aggregates of inflammatory cells and an absence of neutrophils and macrophages (Supplementary Fig. The results suggest that IL-17 plays an important role in influencing the numbers of inflammatory cells as well as the cell type in inflammatory infiltrate organization.
The experienced Th17 cells are capable of inducing gland destruction as well as promoting the growth and maturation of autoreactive B cells.
Autoantibodies produced by the expansion of selective B cells can instigate glandular dysfunction leading to the shutdown of saliva flow.
Interleukin (IL)-17 is one of the critical inflammatory cytokines that plays a direct role in development of Sjögren’s syndrome (Sj S), a systemic autoimmune disease characterized by a progressive chronic attack against the exocrine glands.
The expression levels of IL-17 are correlated with a number of essential clinical parameters such as focus score and disease duration in human patients.
To further define the role of IL-17 in Sj S and elucidate its involvement in the sexual dimorphism, we examined the systemic effect of IL-17 by genetically ablating Il-17 in the C57BL/6. The results indicate that IL-17 is a potent inflammatory molecule in the induction of chemoattractants, cytokines, and glandular apoptosis in males and females.
Recent evidence has indicated that estrogen is capable of inducing Th17 cells by activation of its Rorγt transcription factor, however its role in glandular apoptosis, B cell function, and sexual dimorphism has not been examined.
In the present study, we sought to test the hypothesis that Th17 cells are unique antigen-specific T cells responsible for the development of autoantibodies, which target the destruction of the salivary glands and explore whether a sex difference in IL-17 exists in a spontaneous Sj S B6. Our results demonstrate that the elimination of IL-17 restored gland secretory function and reduced sialadenitis more drastically in females.
NOD-Aec1Aec2 mice, followed by lymphocytic infiltration at approximately 16–20 weeks of age in male and female B6.
NOD-Aec1Aec2 mice, preceded by the loss of secretory function in both sexes mice than the male counterpart during the adaptive phase with progressive severity during the clinical-disease phase.
The result supports a much more important role for IL-17 and demonstrates the sexual dimorphic function of IL-17 in Sj S.